Statins decrease the efficacy of Plavix (clopidogrel)

  Years ago, researchers used to think so.

  Some platelet studies suggested that atorvastatin or simvastatin inhibit the antiplatelet effects of clopidogrel.

  It was thought that since these statins and clopidogrel are both substrates for CYP450 3A4, that they might compete...reducing the effects of Plavix.

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