Watch for Unexpected Ingredients in New Zantac Products

The new OTC Zantac 360° products will lead to confusion.

Many people will assume these contain the acid reducer ranitidine like the original Zantac...but they don't.

Zantac 360° actually contains Pepcid AC.

Explain that OTC and Rx ranitidine products are still off the market in the U.S...due to concerns about the impurity NDMA (N-nitrosodimethylamine).

Expect mix-ups. Think of this as similar to how Sudafed contains pseudoephedrine, but Sudafed PE has phenylephrine...or how Dulcolax contains bisacodyl, but Dulcolax Soft Chews have magnesium hydroxide.

Point out product labeling to patients. Zantac 360° Original Strength is 10 mg famotidine...Maximum Strength is 20 mg famotidine.

Keep in mind, the "360" in Zantac 360° might nod to its reformulation...but doesn't refer to strength, dosing, or quantity.

If patients get Zantac 360°, double-check their med lists for other famotidine help prevent doubling up.

Clarify any Rxs or med lists that include "Zantac." It could refer to ranitidine or famotidine.

Use both brand AND generic names for Zantac 360° in written or verbal help limit mishaps.

See our chart, OTC Brand-Name Extensions, for more examples of confusing OTC brand names and their ingredients.

Key References

  • ISMP Med Safety Alert! Community/Ambul Care 2021;20(5):1-4; AA1-AA4
  • (6-22-21)
  • (6-22-21)
Pharmacy Technician's Letter. July 2021, No. 370709

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