New Generics and Biosimilars = New Risks for Substitution

December 2025

Many big drugs are going generic or getting biosimilars.

Watch for potential formulary changes...and substitution errors.

Generic liraglutide (Saxenda) is the first generic GLP-1 agonist for obesity. But it still costs about $1,170/month versus $1,350 for Saxenda.

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Table of Contents

Sinusitis Expect a “Watch and Wait” Approach for Acute Sinusitis
Opioid Antagonists Help Boost Access to Naloxone or Nalmefene
New Generics New Generics and Biosimilars = New Risks for Substitution
Endocrinology Watch for Creative GLP-1 Agonist Dosing
Med Safety Prevent Mishaps With Weight-Based Meds
Osteoporosis Help Patients Get the Most Out of Their Osteoporosis Meds
Med Safety Watch for Errors With Central Fill Rxs
NatMed Spotlight Sort Out Claims About Supplements for Cold and Cough