Valproate (Depakote, etc) can increase levels of amitriptyline

October 1996

Valproate (Depakote, etc) can increase levels of amitriptyline...and possibly other tricyclic antidepressants as well.

This is important because valproate is being used more for bipolar disorder and migraines. These patients might also get amitriptyline...making an interaction more likely.

Valproate inhibits the metabolism of amitriptyline...increasing amitriptyline levels about 20%.

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