Boxed warning about which patients shouldn't take metformin (Glucophage)

    Bristol-Myers Squibb is strengthening their boxed warning about which patients shouldn't take metformin (Glucophage).

    Metformin can cause lactic acidosis...especially in patients with predisposing risk factors.

    These are patients with decreased renal function...congestive heart failure...advanced age...excessive alcohol intake...or chronic respiratory insufficiency.

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