patients on Allegra who say it doesn't work

June 2001

Do you have patients on Allegra who say it doesn't work? Do they take it with fruit juice?

Preliminary evidence suggests that bioavailability of Allegra is almost 70% less when taken with apple, grapefruit, or orange juice.

Don't confuse this with the well-known grapefruit juice interactions. Grapefruit inhibits CYP450 3A4 and INCREASES absorption of certain drugs...lovastatin, protease inhibitors, nifedipine, etc.

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