drug interaction alerts between methotrexate and "PPI" stomach acid reducers (omeprazole, pantoprazole, etc)

You'll encounter drug interaction alerts between methotrexate and "PPI" stomach acid reducers (omeprazole, pantoprazole, etc).

PPIs can boost methotrexate levels...possibly leading to liver damage, immune system suppression, and death.

The higher the dose of methotrexate, the higher the risk of toxicity. But problems can still occur with lower doses.

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