Methylene Blue: Evidence Review

January 2026

You’ll hear methylene blue supplements touted to improve cognition, boost athletic performance, slow aging, and more.

As an Rx injectable, methylene blue is used in acute care as a surgical dye and to treat methemoglobinemia, vasoplegia, etc.

Now oral versions of this synthetic blue dye are trending as a “mitochondrial booster”...to improve cellular health.

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Table of Contents

Obesity & Weight Loss Listen for New Side Effect Concerns With GLP-1 Agonists
Practice Point Out Caveats With Direct-to-Consumer Meds
Menopause Watch for Elinzanetant for Menopausal Hot Flashes
Asthma Clear the Air on Asthma Treatment for Kids
Hair Loss Untangle Mix-Ups With Meds for Male Pattern Baldness
Pediatrics Stay Alert for Meds on the “KIDs List” to Keep Children Safe
Education and Training Weave AI Into Your Plan for Training Learners
NatMed Spotlight Methylene Blue: Evidence Review