precaution about using Pondimin with serotonergic drugs

July 1996

The new labeling will also include a precaution about using Pondimin with serotonergic drugs such as Prozac...too much chance the combination will have additive effects and increase serotonin levels.

In severe cases, this can trigger "serotonin syndrome"...a life-threatening emergency. These patients show up in the ER with high blood pressure...high temperature...agitation...and seizures.

Physicians treat serotonin syndrome with a benzodiazepine for seizures...and sometimes a serotonin blocker such as cyproheptadine (Periactin) or methysergide (Sansert).

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